前丘脑偏好驱动全心,但不是自我中心的定向调整在后鼻皮层
Patrick A LaChance1, Jeffrey S Taube2
1Department of Psychological and Brain Sciences, Dartmouth College, Hanover, New Hampshire 03755.
概括
前丘脑 (ATN) 影响后后皮层 (POR) 中的头部方向 (HD) 细胞,影响空间导航. 这表明POR通过ATN投影整合了自我中心和非中心的空间信息.
科学领域:
- 神经科学是一个神经科学.
- 空间认知 空间认知
- 行为神经科学 行为神经科学
背景情况:
- 空间导航依赖于整合非中心和自我中心的参考框架.
- 后后皮层 (POR) 参与整合头部方向 (HD) 和自我中心的空间信息.
- 波尔高清信号的确切来源,特别是它们的偏心性与视觉地标响应相比,仍然不清楚.
研究的目的:
- 调查前丘脑 (ATN) 在调节头部方向 (HD) 细胞活动中的前丘脑 (ATN) 在后后皮层 (POR) 的作用.
- 为了确定POR高清信号是否真正是偏心的或受视觉地标的影响.
- 澄清POR作为空间表示的集成枢纽的功能.
主要方法:
- 在雌性大鼠的POR中记录了头部方向 (HD) 细胞活动.
- 双边禁用前丘脑 (ATN),以评估其对POR细胞的影响.
- 分析了发射速率,调节强度和偏心位置编码的变化.
主要成果:
- ATN 失活显著降低了 POR HD 电池的发射速度和调强度.
- 在ATN无活化后,通过结合性HD/自我中心细胞观察到异心位置编码的破坏.
- 缺少高清调的POR自我中心细胞在很大程度上不受ATN无活化的影响.
结论:
- 脑后皮层 (POR) 中的头部方向 (HD) 信号至少部分依赖于前丘脑 (ATN) 的投射.
- 这些发现支持了POR作为一个关键的集成中心的角色,以集成自我中心和非中心的空间表征.
- 这项研究阐明了大脑中空间参考框架集成背后的神经机制.
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