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背景和时间调节恐惧记忆 巩固和重新巩固在底侧杏仁体综合体中的恐惧记忆
Jessica Leake1, Luisa Saavedra Cardona1, Filip Mencevski1
1School of Psychology, University of New South Wales, Sydney, New South Wales 2052, Australia.
概括
基底侧杏仁体中的蛋白质合成并不总是需要用于恐惧记忆的巩固. 它的必要性取决于过去经验的相似性,时间和背景.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 分子神经科学 分子神经科学
背景情况:
- 传统上,恐惧记忆的巩固与底侧杏仁核复合体 (BLA) 中的蛋白质合成有关.
- 最近的发现表明,如果它们与以前的经历相似,蛋白质合成可能不必用于巩固新的恐惧记忆.
研究的目的:
- 调查体验的空间和时间分离如何影响恐惧记忆巩固中蛋白质合成的要求.
- 确定语境相似性和提醒是否影响恐惧记忆中的蛋白质合成依赖性.
主要方法:
- 老鼠经历了两阶段的恐惧调节范式,阶段之间有不同的时间和上下文分离.
- 一种蛋白质合成抑制剂 (cycloheximide) 或载体在条件化后被注入到BLA中.
- 使用有条件刺激 (S2) 测试恐惧记忆回忆.
主要成果:
- 当训练阶段在时间 (48小时) 和背景上相似时,BLA中不需要蛋白质合成来巩固恐惧记忆.
- 巩固需要蛋白质合成,当训练阶段是遥远的 (14d) 或在不同的背景下.
- 在延迟后或在新的环境中重新暴露于最初的刺激 (S1),取消了蛋白质合成要求.
- 对恐惧记忆的再巩固还显示了基于时间和上下文因素的可变蛋白质合成要求.
结论:
- 在底侧杏仁体综合体中对蛋白质合成的要求,以巩固和重新巩固恐惧记忆并不是绝对的.
- 诸如体验相似性,时间近距离,空间上下文和记忆提醒等因素极大地调节了这一要求.
- 这些发现凸显了BLA中恐惧记忆处理的动态性质.
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