结合心脏代谢深度表型和基于登记册的Inter99队列20年后续研究的协议
Kirsten Schroll Bjørnsbo1, Charlotte Brøns2, Mette Aadahl1
1Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.
BMJ open
|January 29, 2024
概括
这项研究调查了Inter99队列中的心脏代谢疾病,重点关注深度表型,以了解2型糖尿病 (T2D) 和心血管疾病轨迹. 它检查低出生体重是否预测以后的并发病,独立于其他因素.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 1999年建立的Inter99队列,包括30-60岁的个体,对于了解2型糖尿病 (T2D) 和心血管疾病 (CVD) 的病因和干预效应至关重要.
- 这项基于丹麦哥本哈根大区的人口的研究包括生活方式干预和参考组,并对心血管风险因素和糖尿病前期疾病进行基线查.
研究的目的:
- 对Inter99参与者 (现年50-80岁) 进行深入的表型和注册后续调查,以阐明早期和明显心脏代谢疾病的原因,轨迹和模式.
- 调查低出生体重对常见T2D心脏代谢并发症在以后的生活中的独立预测作用.
主要方法:
- 一项对6004名参与者的20年后续临床检查,包括人体测量,血压,动脉硬,心脏代谢生物标志物,冠状动脉化,心率变化,心律,肝硬,底部特征,肌肉强度和质量以及问卷.
- 亚样本分析包括对饮食,体力活动和持续葡萄糖测量的10天监测,并为生物银行采集样本.
主要成果:
- 目前正在进行深度表型化和注册表后续工作的数据收集.
- 分析的重点是确定心脏代谢疾病的轨迹和风险因素,包括低出生体重的影响.
结论:
- 这项研究旨在为心脏代谢疾病的多因素病因提供新的见解.
- 预计这些发现将为公共卫生战略和2型糖尿病和心血管疾病的临床管理提供信息.
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