怀孕期间高血压患者服用抗抑郁药的风险:一项回顾性队列研究
Marlieke Oude Weernink1, Elvera A Damer2, Mireille A Edens3
1Department of Clinical Pharmacy, Isala Klinieken, dr van Heesweg 2, 8025 AB, Zwolle, The Netherlands.
Archives of gynecology and obstetrics
|January 29, 2024
概括
在患有高血压的孕妇中使用抗抑郁药并没有影响出生体重或Apgar分数. 虽然存在潜在的孕妇产科高级护理入院的风险增加,但没有发现其他重要的孕妇或新生儿风险.
科学领域:
- 产科和妇科 产科和妇科
- 产周医学 产周医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 高血压疾病会使怀孕复杂化,需要用抗高血压药物进行治疗.
- 在这个人群中,抗抑郁药的使用是越来越令人担忧的,因为潜在的风险.
- 现有的关于怀孕期间抗抑郁药安全性与并发症的研究是有限的.
研究的目的:
- 调查抗抑郁药使用与患有高血压疾病的妇女不良妊娠结果之间的关联.
- 为了比较暴露和未暴露组之间的出生体重,APGAR分数和新生儿重症监护室 (NICU) 的入院情况.
- 评估母亲入院到产科重症监护室 (OHC) 的风险.
主要方法:
- 追溯的队列研究.
- 包括使用抗高血压药物的孕妇,比较抗抑郁药物暴露与没有暴露.
- 分析主要结果 (出生体重) 和次要结果 (APGAR分数,NICU,OHC入院).
主要成果:
- 使用抗抑郁药的母亲和不使用抗抑郁药的母亲之间没有观察到新生儿出生体重的显著差异.
- APGAR分数和新生儿重症监护室 (NICU) 的入院没有显著差异.
- 在暴露于抗抑郁药的组中,注意到母亲入院产科高级护理 (OHC) 的潜在风险增加.
结论:
- 在高血压的孕妇中使用抗抑郁药似乎不会增加出生体重,APGAR分数或NICU入院的风险.
- 抗抑郁药使用与母亲OHC入院之间的可能联系需要进一步调查.
- 在这个特定的患者群体中,在处方抗抑郁药的使用中,没有发现额外的孕产妇或新生儿风险.
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