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多发性硬化症患者的孤立认知障碍:频率,MRI模式及其随时间的发展

Piet M Bouman^1,2, Maureen A van Dam^3,4,5, Laura E Jonkman^4,6

¹Department of Anatomy and Neurosciences, MS Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC VUmc, De Boelelaan 1117, Amsterdam, The Netherlands. p.bouman@amsterdamumc.nl.

Journal of neurology

|January 29, 2024

概括

孤立认知障碍在患有多发性硬化症 (PwMS) 的人群中很常见,可以预测未来的衰退,特别是在处理速度方面. 早期检测和干预是管理MS认知变化的关键.

科学领域:

神经科学是一个神经科学.
神经学神经学
放射学放射学是一门学科.

背景情况:

在患有多发性硬化症 (PwMS) 的人群中,认知障碍很普遍.
了解孤立认知障碍的频率,MRI相关性和纵向发展对于有效管理至关重要.

研究的目的:

确定PwMS中孤立认知障碍的频率.
为了确定与单域认知缺陷相关的特定MRI相关物.
检查五年来孤立认知障碍的纵向进展.

主要方法:

348名PwMS在基线和五年后期接受了神经心理测试.
孤立认知障碍被定义为在单个认知领域中,Z-score至少低于标准数据的1.5 SD.
结构性MRI被用来探索与认知功能的相关性.

主要成果:

在基线时,31%的PwMS患有孤立的认知障碍,执行功能/工作记忆是受影响最严重的领域.
信息处理速度 (IPS) 的孤立损伤与皮质体积和分数异质性有关.
记忆障碍与皮质和海马体积相关.
在69%的PwMS患者中观察到认知能力下降,在5年后,在基线时与孤立的IPS损伤有关.

结论:

孤立的认知障碍在PwMS中很常见,可能表明未来的认知能力下降,特别是当影响处理速度时.
皮层和深灰质缩是孤立认知障碍的重要因素.
早期检测和量身定制的干预措施,特别是处理速度缺陷,可能有助于减轻PwMS的进一步认知衰退.

关键词:

认知认知是一种认知.认知康复认知康复认知康复孤立的认知障碍孤立的认知障碍这就是为什么MRI是MRI.多发性硬化症是多发性硬化症.

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