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Updated: Jul 4, 2025

Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique
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在HCN心脏起器通道中,对cAMP的高亲和度切换器.

Alessandro Porro1, Andrea Saponaro2, Roberta Castelli1

  • 1Department of Biosciences, University of Milan, Milano, Italy.

Nature communications
|January 29, 2024
PubMed
概括

超极化激活循环核酸封闭 (HCN) 通道具有对cAMP的亲和性开关. 阿尔法螺旋体D和E稳定了循环核酸结合域,显著增加了cAMP的结合亲和力和有效性.

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