家庭生活方式干预计划可以降低三阴性乳腺癌细胞的瘤生成潜力
Giulia Baldelli1, Valentina Natalucci2, Carlo Ferri Marini2
1Unit of Pharmacology and Hygiene, Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029, Urbino, Italy.
Scientific reports
|January 29, 2024
概括
在乳腺癌幸存者中,饮食和运动等生活方式的改变略有降低了乳腺癌细胞瘤发生潜力. 胰岛素类生长因子1 (IGF-1) 被确定为细胞增殖的关键预测因子.
科学领域:
- 在瘤学瘤学.
- 翻译研究是翻译研究.
- 生活方式 医学 医疗
背景情况:
- 生活方式的修改,包括营养和运动,越来越多地被认为对治疗慢性疾病的作用.
- 乳腺癌幸存者经常面临维持健康生活方式的挑战,这会影响长期健康和复发风险.
研究的目的:
- 为了研究12周的家庭生活方式干预对乳腺癌细胞瘤发生潜力的影响.
- 确定与生活方式干预后癌细胞增殖变化相关的生理和代谢预测因素.
主要方法:
- 血清样本从乳腺癌幸存者在12周的生活方式干预 (营养咨询和结构化炼) 之前 (PRE) 和之后 (POST) 收集.
- 三重阴性乳腺癌细胞 (MDA-MB-231) 用PRE和POST血清在3D条件下培养.
- 球状球形形成 (瘤发生潜力的衡量标准) 在化3周后进行评估.
主要成果:
- 与PRE干预血清相比,POST干预收集的血清显示了球状体形成的显著减少.
- 胰岛素样生长因子1 (IGF-1) 被确定为3D细胞增殖的唯一预测因子,与瘤发生潜力相关.
结论:
- 12周的家庭生活方式干预,包括营养和运动,可以调节乳腺癌细胞的瘤生成潜力.
- 生活方式干预是预防三级癌症的有希望的策略,有可能减少癌症的进展和复发风险.
- 翻译性研究对于了解癌症幸存者的生活方式改变引起的代谢和生理变化至关重要.
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