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Updated: Jul 4, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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来自PACE和OPTIC试验的慢性阶段慢性髓性白血病 (CP-CML) 患者中波纳替尼的剂量修改动态

Elias Jabbour1, Jane Apperley2, Jorge Cortes3

  • 1The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ejabbour@mdanderson.org.

Leukemia
|January 29, 2024
PubMed
概括

波纳替尼有效治疗耐其他药物耐药的慢性髓性白血病 (CML). 与PACE试验相比,OPTIC试验中的新剂量策略降低了心血管风险,改善了患者的安全性.

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