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Updated: Jul 4, 2025

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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针对PDE4A治疗潜力:通过虚拟查和分子动态利用药物重定向方法来利用PDE4A治疗潜力

Anas Shamsi1, Mohd Shahnawaz Khan2, Nojood Altwaijry2

  • 1Center for Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates.

Journal of biomolecular structure & dynamics
|January 30, 2024
PubMed
概括

这项研究确定了FLUSPIRILENE和Dihydroergocristine作为FDA批准药物的潜在PDE4A抑制剂. 这些化合物表现出强烈的结合亲和力,为各种疾病提供新的治疗途径.

关键词:
对于cAMP特有的3′,5′-循环二酶4A,它们具有特定的3′,5′-循环二酶特征.这是一种二能高克里斯胺 (dihydroergocristine).药物重用是为了改变药物的用途.弗卢斯皮里伦 (Fluspirilene) 是一种制剂.虚拟选 虚拟选 虚拟选

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