代谢对多系统健康衰老的影响 跨生命周期健康衰老
Shanshan Yao1, Laura A Colangelo2, Andrew S Perry3
1University of Pittsburg, Pittsburgh, Pennsylvania, USA.
Aging cell
|January 30, 2024
概括
代谢健康对于健康的衰老至关重要,它会影响整个生命周期的身体组成,表现和疾病风险. 了解这些代谢联系可以预测长期的健康结果.
科学领域:
- 老年学是一门学科.
- 代谢学 代谢学 代谢学
- 系统生物学 系统生物学
背景情况:
- 衰老的特点是整个器官系统的代谢失调,导致功能减弱和发病率增加.
- 代谢,衰老和整个生命周期的全系统表型之间的复杂相互作用尚未完全理解.
研究的目的:
- 为了研究代谢,衰老和整个生命周期的全系统表型之间的复杂相互作用.
- 确定与衰老相关的表型的代谢相关物质及其与长期健康结果的关联.
主要方法:
- 利用LASSO-PCA和生物信息技术对健康,衰老和身体组成研究 (N=2469) 和年轻成年人冠状动脉风险发展研究 (CARDIA) (N=2320) 的数据进行了研究.
- 从横截面的代谢组-现象关系中提取了代谢得分,并将它们与9-30年的纵向衰老表型和结果联系起来.
主要成果:
- 确定了七个衰老领域的代谢相关物质的显著重叠,突出了细胞能量,宿主-共生代谢,炎症和氧化应激的途径.
- 四个关键的新陈代谢得分 (身体组成,精神和身体表现,肌肉强度,身体活动) 与健康的衰老和事件结果密切相关.
- 成年早期的代谢得分预测了心血管,代谢和神经认知表现,以及长期的心血管疾病和死亡率.
结论:
- 保存的代谢状态与特定领域的衰老和生命过程结果密切相关.
- 成年早期的代谢健康可以预测衰老轨迹和长期疾病风险.
- 代谢分数为评估健康衰老和预测健康结果提供了宝贵的工具.
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