橄叶提取物对心脏代谢风险因素的影响:随机临床试验的系统审查和元分析
Andressa Anelo Álvares1, Anderson Garcêz1, Lucas Tolio Silva2
1Nutrition Sciences Graduate Program, Department of Nutrition, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, RS, Brasil.
Nutrition reviews
|January 30, 2024
概括
橄叶提取物 (OLE) 对成人心脏代谢风险因素没有显著的益处. 需要进一步的研究来证实对葡萄糖代谢,血压和脂质概况的影响.
科学领域:
- 营养科学 营养科学
- 心血管健康 心血管健康
- 代谢健康 代谢健康
背景情况:
- 橄叶提取物 (OLE) 富含有益的化合物.
- 心血管疾病是全球主要的死亡原因.
- 了解OLE对心脏代谢健康的影响至关重要.
研究的目的:
- 系统地审查OLE对成人心脏代谢风险因素的影响.
- 评估OLE对葡萄糖代谢,血压,脂质概况和炎症标志物的影响.
- 评估随机临床试验的证据质量.
主要方法:
- 在PubMed,EMBASE和Web of Science数据库中进行系统搜索,截至2021年8月.
- 包括12个随机临床试验 (RCT) 与成年参与者 (≥18岁).
- 使用RoB2工具评估偏差风险,使用GRADE系统评估证据质量.
主要成果:
- 分析表明,在低剂量的OLE时,对照组的空腹血糖明显有利于控制组的结果.
- 在一些试验中,观察到葡萄糖代谢,血压,脂质概况和炎症标志物的积极相关性.
- 包括RCT的随访期从2天到12周,涉及703名患者.
结论:
- 与对照组相比,低剂量的OLE并没有显著改善空腹血糖.
- 需要进一步严格的临床研究和一致的方法来验证OLE的影响.
- 目前的证据表明需要更多的研究来确定OLE对心脏代谢健康的有效性.
更多相关视频
07:03Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
905
00:04A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
10.7K
相关概念视频
Exercise and Cardiovascular Response
812
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
812
Overview of Lipid Metabolism
1.6K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.6K
Psychoneuroimmunology: Cardiovascular Disease
31
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
31
