在细胞癌中,N6-甲基氨酸调节剂介导的甲基化修饰模式具有明显的预后,氧化应激和瘤微环境
Chunyang Li1, Maoshu Zhu2, Chuane Gao3
1Department of General Surgery at The Fifth Hospital of Xiamen, 361101 Xiamen, Fujian, China.
Frontiers in bioscience (Landmark edition)
|January 30, 2024
概括
N6-甲基氨酸 (m6A) 修饰在细胞癌 (RCC) 进展中起作用. 一个m6A得分可以预测患者的生存率和对免疫疗法和向疗法的反应,有助于治疗策略.
科学领域:
- 在瘤学瘤学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 分子生物学分子生物学
背景情况:
- 越来越多地认识到N6-甲基氨酸 (m6A) 修饰在癌症发展中的作用.
- 了解m6A对细胞癌 (RCC) 的影响对于推进治疗策略至关重要.
研究的目的:
- 系统地分析m6A修饰在细胞癌 (RCC) 进展中的作用.
- 开发一个量化测量m6A修饰模式在个别的RCC患者.
主要方法:
- 从癌症基因组图谱 (TCGA) 的893个RCC标本中对23个m6A调节者的无监督聚类.
- 使用主要组件分析 (PCA) 开发一个m6A评分系统.
- 使用GSVA,ssGSEA和药物数据库 (GDSC,CTRP,PRISM) 评估信号通路,免疫细胞透,癌症免疫周期和药物敏感性.
主要成果:
- 确定了五种不同的m6A修饰亚型,与生存,氧化应激,茎性,免疫透和PD-1/PD-L1表达相关.
- 高的m6A得分与改善的生存率有关,并在抗PD-1/PD-L1免疫疗法队列中得到验证.
- 高m6A得分表明对阿克西替尼布,帕佐帕尼布和索拉芬尼布的敏感性增加,对苏尼替尼布的敏感性降低.
结论:
- m6A修饰广泛调节氧化应激,瘤微环境和RCC中的免疫力.
- 量化m6A评分可能会提高免疫疗法疗效,并指导开发更有效的RCC治疗方法.
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