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开发可移植人类iPSC衍生的细胞的人性化动物模型.
Min Ma1, Jian-Yun Ge2, Yun-Zhong Nie3
1Institute of Regenerative Medicine, and Department of Dermatology, Affiliated Hospital of Jiangsu University, Jiangsu University, 212001 Zhenjiang, Jiangsu, China.
Frontiers in bioscience (Landmark edition)
|January 30, 2024
概括
人性化的动物模型提供了改进的疾病建模和药物查. 干细胞技术的进步正在为生物医学研究创造更准确的人类模型.
科学领域:
- 生物医学研究生物医学研究
- 翻译科学 翻译科学
- 动物建模动物建模
背景情况:
- 传统的动物模型与人类有显著的生理和免疫学差异,这阻碍了研究结果的翻译.
- 现有的人性化动物模型面临着植入率和生理功能方面的挑战,这限制了它们与人类类似的准确性.
- 产生完全人性化的动物受到人类移植资源的缺乏和接受者的免疫耐受性不足的阻碍.
研究的目的:
- 总结人性化动物模型的现状,重点关注造血/免疫和肝脏系统.
- 讨论生成人性化的动物模型的策略,强调人类多能干细胞作为捐赠来源.
- 审查这些模型在临床和制药应用中的优势,局限性和新兴趋势.
主要方法:
- 审查基因编辑和基于多能干细胞的异种移植技术的最新进展.
- 综合实验室专业知识的人性化动物模型的生成和表征.
- 分析供体细胞来源,特别是人类多能干细胞,用于异种移植.
主要成果:
- 人性化的动物模型正在进步,重点是造血/免疫和肝脏系统.
- 基于多能干细胞的异种移植为更容易获得的人类类模型提供了一个有希望的途径.
- 在克服与移植和免疫耐受性相关的挑战方面取得了进展.
结论:
- 人性化的动物模型对于推进疾病建模和药物查至关重要.
- 最近的技术进步使得更准确,更可靠的人性化模型的开发成为可能.
- 这些改进的模型对未来的临床和制药应用具有重大潜力.
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