在接受他类药物治疗的已确诊心血管疾病患者中,中间和长期的残留心血管风险
K Vijayaraghavan1, S Baum2,3, N R Desai4
1Division of Cardiology, University of Arizona College of Medicine, Phoenix, AZ, United States.
Frontiers in cardiovascular medicine
|January 30, 2024
概括
尽管使用他类药物治疗,但心血管事件仍然常见于已确诊心血管疾病的患者. 额外的治疗方法,如eicosapentaenoic acid,对于降低残留心血管风险至关重要.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 类药物是心血管 (CV) 事件的二次预防的第一线药物,向低密度脂蛋白胆固醇 (LDL-C).
- 在服用他类药物的患者中,即使LDL-C水平得到良好控制,残留心血管风险仍然存在.
研究的目的:
- 审查当代文献中介和长期事件率的患者与已确定的心血管疾病治疗他类药物.
- 突出需要除了他类药物之外的额外疗法来管理持续的心血管风险.
主要方法:
- 现有研究的叙述性审查.
- 在接受他类药物治疗的已确诊心血管疾病 (冠状动脉疾病,脑血管疾病,外周动脉疾病) 的患者中分析事件发生率.
主要成果:
- 在服用他类药物的患者中,累积的CV事件发生率可以在10年内达到约40%.
- 在外周动脉疾病中观察到高比例的复发性中风 (在7年内高达19%) 和重复的再血管化或心血管死亡 (分别在3年内高达38%和33%).
结论:
- 需要额外的治疗策略,以减轻在接受他类药物治疗的已确诊心血管疾病的患者中持续的CV风险.
- 像eicosapentaenoic酸这样的药物,针对超出LDL-C的途径,显示出进一步降低风险的希望.
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