怀孕期间宿主肠道微生物群的相互作用
Katherine R Amato1, Priyanka Pradhan2, Elizabeth K Mallott1,3
1Department of Anthropology, Northwestern University, Evanston, IL 60208, USA.
Evolution, medicine, and public health
|January 30, 2024
概括
怀孕涉及生理变化,但荷尔蒙变化和肠道微生物可以造成母子冲突. 了解这些相互作用是繁殖进化的关键.
科学领域:
- 生殖生物学 生殖生物学
- 微生物组研究的研究.
- 进化生理学的进化生理学
背景情况:
- 哺乳动物怀孕涉及对胎儿发育的生理适应,影响母亲和后代的健康.
- 怀孕期间母亲的权衡可以导致母子健康冲突.
- 从历史上看,荷尔蒙变化一直与此有关,但肠道微生物群的作用正在出现.
研究的目的:
- 在怀孕期间模拟母亲激素,免疫,新陈代谢和肠道微生物群之间的相互作用.
- 探索这些相互作用如何调解母亲和后代的健康权衡.
- 为了解妊娠微生物群的进化意义提供一个框架.
主要方法:
- 构建一个机械模型,将荷尔蒙,免疫,代谢和微生物变化联系起来.
- 该模型整合了激素通过免疫系统对肠道微生物群的直接和间接影响.
- 该模型还结合了从肠道微生物群到母亲免疫和新陈代谢的反循环.
主要成果:
- 怀孕期间的荷尔蒙波动显著改变了肠道微生物组的组成和功能.
- 母亲的免疫系统在激素变化和肠道微生物群之间起到调解作用.
- 肠道微生物群反过来影响母亲的免疫力和新陈代谢,创造了一个动态的反系统.
结论:
- 拟议的模型强调了肠道微生物群在调解与怀孕有关的健康权衡方面的关键作用.
- 母亲生理学与肠道微生物组之间的相互作用可能取决于背景,并且在不同的人群中存在差异.
- 结合生理学,微生物和健身数据的未来实证研究对于验证这些进化假设至关重要.
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