在巴西,DENV-2基因型II (Cosmopolitan) 的多次引入和全国范围的传播
Tiago Gräf1, Caroline Do Nascimento Ferreira1, Gustavo Barbosa de Lima2
1Laboratório de Virologia Molecular, Instituto Carlos Chagas, Fundação Oswaldo Cruz, Curitiba 81350-010, Brazil.
Virus evolution
|January 30, 2024
概括
登革热病毒血清型2型,基因型Cosmopolitan (DENV-2-GII),已在巴西所有地区检测到. 之前的DENV-2基因型亚裔美国人 (DENV-2-GIII) 循环可能解释其神秘传播和有限的爆发.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 基因组学就是基因组学.
背景情况:
- 登革热病毒血清型2型,基因型Cosmopolitan (DENV-2-GII) 是一种全球流行的病毒株.
- 亚裔美国人DENV-2基因型 (DENV-2-GIII) 历史上主导了美国和巴西的DENV-2流行病.
- 巴西首次报告的DENV-2-GII病例是在2021年.
研究的目的:
- 调查DENV-2-GII在巴西的存在和传播.
- 了解DENV-2-GII.II的引入动态和地理分布.
- 评估DENV-2-GII对巴西登革热景观的影响.
主要方法:
- 在2021年3月至2023年3月期间收集的237个DENV-2阳性样本的测序.
- 植物地理分析以推断引入事件和传播模式.
- 对全国登革热流行病实验室监测数据的分析.
主要成果:
- 在巴西的所有地理区域都发现了DENV-2-GII.
- 在2020年5月至2022年8月期间,至少有四次DENV-2-GII进入巴西.
- 尽管引入,登革热病毒血清型1 (DENV-1) 占据了2022年巴西登革热疫情的主导地位.
结论:
- 现在,DENV-2-GII已经在巴西各地建立并传播.
- 之前接触DENV-2-GIII可能已经形成了免疫屏障,导致了DENV-2-GII的神秘循环.
- 基因组监测对于监测DENV-2-GII和了解其未来影响至关重要.
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