吸烟和PM2.5可能共同加剧代谢综合征的风险
Hao-Hung Tsai1,2,3,4,5, Disline Manli Tantoh3,6, Wen Yu Lu6
1Institute of Medicine, Chung Shan Medical University, Taichung City, Taiwan.
吸烟和细颗粒物 (PM2.5) 独立地增加了代谢综合征 (MS) 的风险. 联合暴露显著增加了MS风险,目前的吸烟者面临的几率最高,特别是高PM2.5水平.
科学领域:
- 环境健康 环境健康
- 心血管疾病流行病学
- 代谢综合征研究 代谢综合征研究
背景情况:
- 吸烟和细颗粒物 (PM2.5) 是导致心血管疾病和死亡率的重要因素.
- PM2.5和吸烟对代谢综合征 (MS) 发展的综合影响尚不清楚.
研究的目的:
- 调查PM2.5暴露和吸烟与台湾成年人患代谢综合征 (MS) 风险的独立和联合联系.
主要方法:
- 这是一项针对126,366名年龄在30至70岁的台湾成年人,没有癌症病史的大规模研究.
- 代谢综合征,吸烟状况和共变量数据来源于台湾生物银行 (TWB).
- 从台湾环境保护局 (EPA) 获取了PM2.5暴露水平,并将其分类为四分位数.
主要成果:
- 暴露于PM2.5和吸烟都与MS的风险增加有显著的关联.
- 较高的PM2.5水平表明MS风险的剂量依赖性增加.
- 与非吸烟者相比,目前吸烟者患MS的风险要高得多,与高PM2.5暴露相结合时,观察到协同效应.
结论:
- PM2.5和吸烟是MS的独立风险因素.
- 吸烟似乎对MS风险的影响比PM2.5暴露更为明显.
- 同时暴露于PM2.5和吸烟都会显著增加患MS的风险.
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