从1989年到2023年对光动力学疗法和免疫反应的图书统计分析
Wanting Fan1, Jianming Tang1, Su Tang1
1Department of Stomatology, Shenzhen People's Hospital, Shenzhen, China.
Frontiers in pharmacology
|January 30, 2024
概括
光动力疗法 (PDT) 激活了免疫反应来对抗瘤. 研究趋势显示,越来越多地关注PDT与免疫疗法和纳米颗粒相结合,以提高抗瘤免疫力.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 摄影化学的使用.
背景情况:
- 光动力疗法 (PDT) 是一种对癌前和癌性病变的微创治疗方法.
- PDT因其刺激宿主免疫反应的能力而闻名.
- 了解PDT免疫反应的研究趋势对于推进癌症治疗至关重要.
研究的目的:
- 对PDT免疫反应的研究趋势和热点进行文献计量分析.
- 绘制该领域出版物的时间和空间分布图.
主要方法:
- 从1989年到2023年,从Web of Science对1688篇文章和评论进行了图书统计分析.
- 使用Citespace和VOSviewer可视化出版模式.
主要成果:
- 自1989年以来,关于PDT和免疫反应的出版物大幅增加.
- 中国科学院和多才多艺的作者 (科尔贝利克,汉布林,陈) 确定.
- 目前的研究重点是基于PDT的树突细胞疫苗,与免疫检查点抑制剂 (ICI) 的组合疗法以及纳米粒子输送.
- 关键基因 (CD8A,TNF,IFNG,CTLA4) 研究了与PDT相关的免疫.
结论:
- PDT有效地消去瘤并增强抗瘤免疫力.
- 本文献分析强调了PDT相关免疫反应的关键研究热点和未来方向.
- 这些发现为开发通过PDT增强抗瘤免疫力的新策略提供了洞察力.
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