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Updated: Jul 4, 2025

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该ORFIUS复合体调节在复制起源的ORC2定位.

Zelei Yang1, Saie Mogre1, Ruiyang He1

  • 1Department of Medical Oncology and Division of Molecular and Cellular Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

NAR cancer
|January 30, 2024
PubMed
概括

在卵巢癌中,BRD1通过形成ORFIUS复合体来抑制复制应激,该复合体调节DNA复制起源. 在高度血清性卵巢癌 (HGSC) 中,这种复合物的失调可能会推动瘤的存活率.

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