Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

2.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.4K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

2.6K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.6K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

940
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
940
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

544
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
544
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

11.1K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.1K
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

174
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
174

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Elective Total Joint Replacement in Patients With Left Ventricular Assist Devices: A Modern Case Series and Systematic Review.

HSS journal : the musculoskeletal journal of Hospital for Special Surgery·2026
Same author

Oral Frailty and Aging: A Systematic Review and Meta-analysis of Oral Health Challenges in the Geriatric Population.

Annals of African medicine·2026
Same author

When Clinical Suspicion Overrides Benign Biopsy: Invasive Pancreatic Intraductal Oncocytic Papillary Neoplasm With Concurrent Neuroendocrine Tumor.

ACG case reports journal·2026
Same author

The impact of remote care on the quality of care of pregnant women with diabetes: a systematic review protocol.

Systematic reviews·2026
Same author

Evaluation and estimation of epidemic trajectories for SARS-CoV-2 from clinical and wastewater data in Gauteng Province, South Africa.

PLOS global public health·2026
Same author

Role of fluorodeoxyglucose positron emission tomography scan in assessing the extent of myocardial viability in patients with left ventricular dysfunction and its impact on patient outcome.

Nuclear medicine communications·2026

相关实验视频

Updated: Jul 4, 2025

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

2.8K

多代糖尿病是一种多代糖尿病.

Jennifer M Thornton1,2, Nishel M Shah1,2, Karen A Lillycrop3

  • 1Department of Academic Obstetrics & Gynaecology, Chelsea & Westminster NHS Foundation Trust, London, United Kingdom.

Frontiers in endocrinology
|January 30, 2024
PubMed
概括

妊娠期糖尿病 (GDM) 增加了母亲和儿童的风险,包括跨世代的2型糖尿病 (T2D). 针对胎儿发育的早期生物标志物和干预措施对于代谢健康至关重要.

关键词:
脂质生成 (adipogenesis) 是一种表观遗传学是指表观遗传学.孕期糖尿病 孕期糖尿病代谢生物组的代谢生物组多代糖尿病是多代糖尿病.跨代糖尿病 跨代糖尿病

更多相关视频

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
10:03

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

25.8K
Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro
09:33

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro

Published on: June 2, 2018

9.1K

相关实验视频

Last Updated: Jul 4, 2025

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

2.8K
A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
10:03

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

25.8K
Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro
09:33

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro

Published on: June 2, 2018

9.1K

科学领域:

  • 生殖生物学 生殖生物学
  • 代谢性疾病是一种代谢性疾病.
  • 发展规划是指发展规划.

背景情况:

  • 妊娠期糖尿病 (GDM) 对母亲和胎儿的代谢健康产生不利影响,增加了2型糖尿病 (T2D) 和后代心血管疾病的风险.
  • 孕产妇的肥胖加剧了GDM对胎儿生长和脂肪生成的负面影响,有助于多代代谢疾病风险.
  • 遗传,表观遗传和代谢因素与GDM发展中的生活方式和环境相互作用.

研究的目的:

  • 探索将母性GDM与不良后代代代谢结果联系在一起的机制.
  • 为了确定GDM风险评估的潜在早期生物标志物.
  • 了解发育规划在调解跨代代谢疾病风险方面的作用.

主要方法:

  • 对导致GDM的遗传,表观遗传和代谢因素的审查.
  • 在GDM中对母亲代谢组变化的分析.
  • 检查子宫内环境对胎儿脂肪生成和胰岛素敏感性的影响.

主要成果:

  • 患有GDM的母亲的后代面临着T2D,心血管疾病和发展GDM本身的更高风险.
  • 孕产妇的肥胖加剧了胎儿的脂肪生成障碍.
  • 孕产妇的新陈代谢变化 (脂肪酸氧化,炎症,胰岛素抵抗) 可能作为早期GDM生物标志物.
  • 作为对GDM的反应,胎儿表观遗传修饰可以调解多代和跨代风险.
  • 子宫内环境影响胎儿的胰岛素敏感性和代谢挑战反应.

结论:

  • 转基因瘤带来了显著的多代代谢风险,受遗传,表观遗传和代谢因素的影响.
  • 通过代谢生物标志物早期识别有风险的妇女是有希望的.
  • 了解发育规划是缓解长期代谢后果和改善人口健康的关键.