多代糖尿病是一种多代糖尿病
Jennifer M Thornton1,2, Nishel M Shah1,2, Karen A Lillycrop3
1Department of Academic Obstetrics & Gynaecology, Chelsea & Westminster NHS Foundation Trust, London, United Kingdom.
Frontiers in endocrinology
|January 30, 2024
概括
妊娠期糖尿病 (GDM) 增加了母亲和儿童的风险,包括跨世代的2型糖尿病 (T2D). 针对胎儿发育的早期生物标志物和干预措施对于代谢健康至关重要.
科学领域:
- 生殖生物学 生殖生物学
- 代谢性疾病是一种代谢性疾病.
- 发展规划是指发展规划.
背景情况:
- 妊娠期糖尿病 (GDM) 对母亲和胎儿的代谢健康产生不利影响,增加了2型糖尿病 (T2D) 和后代心血管疾病的风险.
- 孕产妇的肥胖加剧了GDM对胎儿生长和脂肪生成的负面影响,有助于多代代谢疾病风险.
- 遗传,表观遗传和代谢因素与GDM发展中的生活方式和环境相互作用.
研究的目的:
- 探索将母性GDM与不良后代代代谢结果联系在一起的机制.
- 为了确定GDM风险评估的潜在早期生物标志物.
- 了解发育规划在调解跨代代谢疾病风险方面的作用.
主要方法:
- 对导致GDM的遗传,表观遗传和代谢因素的审查.
- 在GDM中对母亲代谢组变化的分析.
- 检查子宫内环境对胎儿脂肪生成和胰岛素敏感性的影响.
主要成果:
- 患有GDM的母亲的后代面临着T2D,心血管疾病和发展GDM本身的更高风险.
- 孕产妇的肥胖加剧了胎儿的脂肪生成障碍.
- 孕产妇的新陈代谢变化 (脂肪酸氧化,炎症,胰岛素抵抗) 可能作为早期GDM生物标志物.
- 作为对GDM的反应,胎儿表观遗传修饰可以调解多代和跨代风险.
- 子宫内环境影响胎儿的胰岛素敏感性和代谢挑战反应.
结论:
- 转基因瘤带来了显著的多代代谢风险,受遗传,表观遗传和代谢因素的影响.
- 通过代谢生物标志物早期识别有风险的妇女是有希望的.
- 了解发育规划是缓解长期代谢后果和改善人口健康的关键.
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