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胚胎细胞的发育速度和质量对单个出生体重的影响,单个冷解胚胎细胞转移周期中的单个出生体重

Xue Wang¹, YaLing Xiao¹, ZhengYi Sun¹

¹Department of Gynecology Endocrine and Reproductive Center, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Frontiers in endocrinology

|January 30, 2024

概括

在冷解胚胎移植中,胚胎细胞的发育速度和质量不会显著影响单体出生体重. 然而,发育缓慢,质量较差的囊胚细胞可能会增加生女婴的可能性.

科学领域:

生殖医学生殖医学
新生儿结局的结果.
胚胎学胚胎学

背景情况:

辅助生殖技术 (ART) 增加了通过ART怀孕的分娩.
接受ART治疗的婴儿有更高的早产 (PTB),低出生体重 (LBW) 和对妊娠年龄来说小 (SGA) 的风险.
囊胚质量和发育速度对新生儿结局的影响需要进一步研究.

研究的目的:

为了研究胚胎细胞发育速度和质量对单体出生体重的影响.
分析单次冷解芽细胞转移 (FBT) 后的结果.

主要方法:

420个单个FBT周期 (2011年7月至2021年6月) 的回顾性分析.
根据胚芽细胞发育日 (第5或第6天) 和质量 (好或不好) 将患者分为四组.
评估了新生儿结局,包括出生体重,PTB,LBW,VLBW和HBW.

主要成果:

在四组中,没有观察到出生体重或不良出生结果 (PTB,LBW,VLBW,HBW) 的发生率的显著差异.
在调整混因子后,胚胎细胞发育速度和质量与出生体重没有相关性.
发现男性出生比例的显著差异,较少的男性出生于发育缓慢,质量不佳的胚胎囊 (D组).

结论:

囊胞发育速度和质量的对新生儿出生体重的综合影响似乎微不足道.
转移生长缓慢,质量不佳的囊胚细胞可能与分娩女性婴儿的可能性更高有关.
需要进一步的研究来阐明性别比率变化背后的机制,与胚胎细胞特征相关.

关键词:

在FBT和FBT之间.出生时的体重出生时的体重.胚胎囊细胞的发展速度.胚胎细胞质量的质量辛格尔顿 - 辛格尔顿是一个单一的城市.

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