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根据不同的参考方程,螺旋计解释和临床相关性.
Hyun Woo Lee1, Jung-Kyu Lee1, Yong-Il Hwang2
1Division of Respiratory and Critical Care, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.
Journal of Korean medical science
|January 30, 2024
概括
全球肺功能倡议 (GLI) -2012方程可能无法准确评估韩国慢性阻塞性肺病 (COPD) 患者的肺功能. 然而,它的Z-score是评估空气流量限制的可行选择,与患者报告的结果相关.
科学领域:
- 肺部医学 肺部医学
- 呼吸系统生理学 呼吸系统生理学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 慢性阻塞性肺病 (COPD) 的螺旋测量解释通常使用全球肺功能倡议 (GLI) -2012参考方程.
- 韩国开发了一种新的局部参考方程,需要与现有标准进行比较.
- 从COPD患者的不同参考方程中得出的肺功能概况的临床相关性仍然不清楚.
研究的目的:
- 为了比较COPD患者的肺功能参数和患者报告结果 (PRO),使用三个不同的参考方程:Choi's,韩国国家健康和国家检查调查 (KNHANES) -VI和GLI-2012.
- 通过这些方程来评估空气流限制严重性的临床相关性.
- 评估螺旋计结果与PROs.之间的关联.
主要方法:
- 一项涉及2,180名COPD患者的横截面研究.
- 使用Choi,KHANES-VI和GLI-2012的参考方程,估计预测的一秒强制呼吸量 (FEV1) 和强制生命能力 (FVC) 的百分比.
- 分析FEV1/FVC值和PROs之间的关联,包括COPD评估测试 (CAT) 评分,圣乔治呼吸道问卷COPD患者 (SGRQ-C) 评分和六分钟步行距离 (6MWD).
主要成果:
- 与Choi和KNHANES-VI方程相比,GLI-2012方程的预测FEV1和FVC值较低.
- 使用GLI-2012方程,较少比例的患者被归类为FEV1或FVC<80%.
- 尽管预测值有差异,但KHANES-VI和GLI-2012方程之间的FEV1和FVC的Z分数相似.
- 这三个参考方程都显示了FEV1 (%) 和PROs之间的显著关联.
结论:
- GLI-2012参考方程可能不准确地反映韩国COPD人口中的FEV1 (%).
- 从GLI-2012方程中获得的Z-score是评估COPD患者FEV1和空气流限制的潜在可行的工具.
- 类似于其他经过测试的方程,GLI-2012方程与患者报告的结果有显著的相关性,支持其临床实用性.


