自发宫动脉剖析的流行病学:基于人口的研究
Kim J Griffin1, William S Harmsen2, Jay Mandrekar2
1Department of Neurology (K.J.G., R.D.B., Z.K.), Mayo Clinic, Rochester, MN.
Stroke
|January 30, 2024
概括
宫动脉剖析 (CeAD) 发生率从2002年到2020年增加了近四倍,特别是在女性中,可能是由于非侵入性成像增加. 这项研究强调了近二十年来CeAD检测的显著增加.
科学领域:
- 神经学 神经学
- 血管医学 血管医学
- 流行病学 流行病学
背景情况:
- 宫动脉剖析 (CeAD) 占年轻成年人中15-25%的缺血性中风.
- 先进的非侵入性成像对CeAD检测率的影响尚不清楚.
- 之前的估计显示,CeAD的每年发病率为每10万人/年2.6人.
研究的目的:
- 为了确定目前的Olmsted县,MN的CeAD发病率.
- 分析2002年至2020年CeAD发病率的趋势.
- 研究非侵入性成像对CeAD检测率的影响.
主要方法:
- 基于人口的回顾性观察队列研究,使用罗切斯特流行病学项目.
- 包括诊断为内动脉或脊椎动脉剖析的成年居民 (2002-2020年).
- 排除严重创伤或仅内干涉后的CeAD;计算年龄和性别调整后的发病率.
主要成果:
- 确定了123例CeAD病例:63个内动脉,54个脊椎,4个常见的动脉剖析.
- 总体而言,自发性CeAD发生率为每10万人/年4.69.
- 发生率显著增加,从每10万人/年的2.30 (2002-2006) 增加到每10万人/年的8.93 (2017-2020) (P<0.0001).
结论:
- 自发性CeAD发生率在2002年至2020年之间增加了近四倍.
- 在研究期间,女性的发病率显著增加了12倍以上.
- CeAD发病率的增加与非侵入性血管成像技术的使用增加密切相关.
相关概念视频
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Aneurysm I: Introduction
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...


