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基托桑涂层大豆蛋白分离物/莱西丁纳米颗粒,用于增强植物醇的稳定性和生物可访问性

Ming Cheng^1,2, Ye Tao^1,2, Chunwei Wang^2,3

¹Department of Food Science and Pharmaceutics, Zhejiang Ocean University, Zhoushan, China.

Journal of the science of food and agriculture

|January 30, 2024

概括

酸盐涂层的植物纳米颗粒 (CS-PNP) 是为了增强降胆固醇效果而开发的. 这种配方显著改善了植物的生物可访问性,显示了功能性食品的潜力.

科学领域:

食品科学与技术食品科学与技术
纳米技术纳米技术
营养保健品营养保健品

背景情况:

植物 (PS) 提供健康益处,特别是降低胆固醇.
有限的溶解性和生物可访问性阻碍了植物在功能性食品中的应用.

研究的目的:

开发酸盐涂层植物纳米颗粒 (CS-PNP) 以提高PS的溶解性和生物可访问性.
评估CS-PNP的稳定性和体外消化性能.

主要方法:

通过自组装制备的桑涂层PS纳米粒子 (CS-PNP).
纳米粒子属性的表征 (大小,泽塔潜力,EE,LA).
优化基托桑度和pH值.
在体外消化研究评估稳定性和生物可访问性.

主要成果:

优化的CS-PNP (0.4 mg/mL CS,pH 3.5) 实现了>90%的EE和187.7nm的大小.
CS-PNP表现出良好的热稳定性,但对盐离子敏感.
CS涂层保护PS免受素水解,但聚合发生在中性条件下.
在体外消化增加了PS生物可访问性从18.2%到63.5%与CS-PNP.

结论:

酸盐涂层的纳米颗粒是口服植物的有效载体.
这种多层系统显示出作为食品中的营养药物交付工具的承诺.

关键词:

生物可访问性生物可访问性基托桑涂层的植物纳米颗粒一层一层的自组装.稳定的稳定性稳定的稳定性

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