在接受甲福明治疗后的新生儿结局妊娠糖尿病:基于人口的队列研究
Johanna Molin1, Magnus Domellöf1, Christel Häggström2
1Department of Clinical Sciences, Umeå University, Umeå, Sweden.
Acta obstetricia et gynecologica Scandinavica
|January 30, 2024
概括
孕期糖尿病的梅特福林治疗显示,新生儿低血糖的风险与单独的营养治疗相比相当,可能是由于养习惯. 与胰岛素治疗相比,甲胺还显示了较低的风险.
科学领域:
- 周围生理学 周围生理学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 新生儿研究新生儿研究
背景情况:
- 新生儿低血糖是妊娠糖尿病的一个显著并发症.
- 孕期糖尿病的母亲的治疗选择会影响新生儿的结果.
- 评估甲胺在治疗妊娠期糖尿病中的作用至关重要.
研究的目的:
- 为了比较新生儿低血糖症的风险,暴露于甲福明 (单独或与胰岛素) 的后代与营养治疗或单独胰岛素的风险.
- 调查不同孕妇妊娠糖尿病治疗组的二次新生儿结局.
主要方法:
- 瑞典 (2019-2021) 基于人口的队列研究,包括16,181名妊娠期糖尿病妇女.
- 用于多变量后勤回归的个体级,链接注册数据.
- 使用调整的几率比率 (aOR) 估计的风险与95%的置信区间 (CI).
主要成果:
- 甲福明治疗与较低的新生儿低血糖风险相比,营养治疗和单独胰岛素治疗有关.
- 与胰岛素结合的甲福明显示出与营养治疗相似的风险,但风险低于单独胰岛素.
- 暴露于胰岛素 (有或没有甲福明) 增加了对妊娠年龄来说很大的风险;药物治疗降低了低Apgar分数的风险.
结论:
- 在甲福明和营养治疗之间,新生儿低血糖症的相似风险可能会受到补充养实践的影响.
- 与胰岛素相比,使用甲福明降低了新生儿低血糖的风险,这并不能由养习惯来解释.
- 需要进一步的研究来澄清甲胺对新生儿低血糖风险的具体影响.
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