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Updated: Jul 4, 2025

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
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时间设计:灵活和可访问的蛋白质序列设计与卷积神经网络

Leonardo V Castorina1, Suleyman Mert Ünal2, Kartic Subr1

  • 1School of Informatics, University of Edinburgh, 10 Crichton Street, Edinburgh EH8 9AB United Kingdom.

Protein engineering, design & selection : PEDS
|January 30, 2024
PubMed
概括

深度学习,特别是卷积神经网络 (CNN),与传统基于物理的方法相比,为蛋白质序列设计提供了更快,更有效的方法. 本研究介绍了TIMED-Design,这是一个应用这些先进的CNN模型用于蛋白质工程的工具.

关键词:
阿尔法 折叠 2 2卷积神经网络 (CNN) 是一种神经网络.蛋白质序列设计的设计使用者界面 (UI)

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Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
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