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Updated: Jul 4, 2025

Construction of Cell-based Neurotransmitter Fluorescent Engineered Reporters CNiFERs for Optical Detection of Neurotransmitters In Vivo
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基于GPCR的神经调节器的基因编码光指示器的工程,应用和未来前景

Valentin Lu Rohner1, Paul J Lamothe-Molina1, Tommaso Patriarchi1,2

  • 1Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.

Journal of neurochemistry
|January 30, 2024
PubMed
概括

本综述涵盖了G蛋白合受体 (GPCR) 的遗传编码光指标 (GEFI). 它详细介绍了它们的开发,工程,应用以及改善生物传感的未来方向.

关键词:
G-蛋白结合受体的受体.基因编码的光指示器通过神经调节进行神经调节.

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G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
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