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有效的加载和持续交付甲索特雷克萨特使用尖端可吞的微针阵列补丁用于牛皮治疗
Puxuan Zhao1,2, Zhiming Li2, Zhixin Ling2
1College of Materials Science and Engineering, Zhejiang University of Technology, Zhejiang, Hangzhou 310014, China.
ACS biomaterials science & engineering
|January 30, 2024
概括
一种新型的微针贴片可以有效地治疗牛皮,改善皮肤保留和治疗结果,与传统方法相比.
科学领域:
- 生物材料科学 生物材料科学
- 皮肤病学 皮肤病学
- 药物输送系统 药物输送系统
背景情况:
- 甲托雷克萨特 (MTX) 是一种关键的牛皮治疗方法,但由于副作用和通过皮下注射或口服途径的低最佳输送,它面临着局限性.
- 现有的超皮药物输送微针方法遇到诸如药物浪费,剂量不准确和药物停留时间短等挑战.
- 通过微针将MTX直接输送到皮肤病变是克服这些局限性的有希望的策略.
研究的目的:
- 开发和评估可吞的微针阵列补丁 (TSMAP),用于增强载荷和持续输送甲醇 (MTX).
- 研究TSMAP在改善皮肤中MTX保留的疗效及其对牛皮的治疗效果.
- 为了比较TSMAP与传统MTX管理方法的性能.
主要方法:
- 通过微型成型使用光交联甲化氨酸 (MeHA) 和生物相容树脂制造TSMAP.
- 通过控制浸泡和干燥,优化MTX加载到TSMAP尖端.
- 评估TSMAP的皮肤透,药物保留,以及在像牛皮这样的小鼠模型中的体内治疗疗效.
主要成果:
- TSMAP证明了有效的MTX加载和持续释放,其尖端脱离并嵌入皮肤组织.
- 与皮下注射和可溶性微针相比,含MTX的TSMAP显著提高了皮肤中的药物保留率.
- 在体内研究表明,TSMAP介导的MTX输送显著改善了牛皮症状缓解和减少了促炎性细胞因子,优于其他方法.
结论:
- 可吞的微针阵列补丁 (TSMAP) 提供了一个有效的平台,用于持续向皮肤输送甲状腺素.
- TSMAP显著提高了牛皮治疗的治疗结果,超过了传统的施用途径.
- TSMAP为治疗需要局部药物输送的各种皮肤疾病提供了一个有希望的,用户友好的替代方案.
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