在关键的グラム阴性细菌和天然排泄抑制剂中产生排泄介导的多药性耐药性

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Praveena Nanjan¹, Vanitha Bose¹

¹Department of Biochemistry, School of Life Science, Jss Academy of Higher Education and Research, Longwood Campus, Mysuru Road, Ooty, India.

Current drug research reviews

|January 30, 2024

概括

细菌的多药耐药性是一个日益严重的问题,由排泄驱动. 植物衍生的排泄抑制剂 (EPI) 在恢复抗生素对抗耐药性格拉姆阴性病原体的有效性方面表现有前途.

科学领域:

微生物学微生物学
药理学药理学是指药理学的学科.
自然产品化学自然产品化学

背景情况:

微生物中的多药性耐药性 (MDR) 损害了现有的抗生素疗效,需要新的治疗策略.
格拉姆阴性细菌中的排泄积极地将抗生素输出,大大导致MDR和治疗失败.
抑制这些排泄是克服MDR和重新使细菌对抗生素敏感的关键策略.

研究的目的:

审查关键的グラム阴性细菌病原体中流体介导的多药性耐药性.
为了检查近几十年来报告的植物源流量抑制剂 (EPI).
突出植物性EPI在联合治疗中对抗MDR感染的潜力.

主要方法:

对科学数据库 (如PubMed,Scopus) 的文献综述,以研究排泄,格兰阴性细菌中的MDR和植物性EPI.
对已识别的EPI报告的作用机制的分析.
综合了关于植物EPI对各种格拉姆阴性病原体的疗效的研究结果.

主要成果:

溢出是赋予格兰负细菌MDR的主要机制.
许多植物衍生化合物表现出排泄抑制活性.
在临床前研究中,抗生素与植物性EPI的组合证明了对MDR菌株的增强疗效.

结论:

来自植物的排泄抑制剂代表了对抗多药物耐药性的有希望的途径.
结合抗生素和EPI可以恢复老药物的有效性,克服耐药性.
对植物衍生EPI的进一步研究对于开发针对关键的グラム阴性病原体的新疗法至关重要.

关键词:

多种药物耐药性多种药物耐药性组合疗法组合疗法关键的克拉姆阴性细菌.排放的排放.天然排泄抑制剂天然排泄抑制剂新型药物. 新型药物.

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