肢体背中轴:lmx1b在发育,病理,进化和再生中的作用
Alejandro Castilla-Ibeas1, Sofía Zdral1, Kerby C Oberg2
1Department of Cellular and Molecular Signalling, Instituto de Biotecnología y Biomedicina de Cantabria (IBBTEC), CSIC-SODERCAN-University of Cantabria), Santander, Spain.
概括
肢体背部中部图案,对于运动至关重要,由Lmx1b指导. 这篇综述综合了有关四肢发育,进化,-帕特拉综合征和再生的研究.
科学领域:
- 发展生物学 发展生物学
- 进化生物学 进化生物学
- 遗传学 遗传学 是一个
背景情况:
- 肢体解剖学具有独特的背部和腹部部位,用于肌肉功能.
- 在四肢运动和操纵方面,背中背部的模式至关重要.
- 对四肢背中模式的研究落后于其他发展轴.
研究的目的:
- 提供四肢背中中心模式的全面审查.
- 综合有关四肢发育的古典和最新发现.
- 突出Lmx1b在背部命运规范中的作用.
主要方法:
- 文献综述综合了古典和最新的研究.
- 对遗传和分子机制的分析.
- 讨论进化和临床影响.
主要成果:
- Lmx1b 是一个关键的转录因子,它决定了后肢中皮层的命运.
- 背中背部的模式影响了配对附属体的进化.
- LMX1B突变与指甲-帕特拉综合征有关.
- 背中极性可能在数字再生中发挥作用.
结论:
- 肢体的背中部模式对于肢体的功能和进化至关重要.
- 需要进一步的研究才能充分理解这一关键的发育过程.
- Lmx1b的作用从发育到疾病和再生.
相关概念视频
01:33Pleiotropy
40.5K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
40.5K
01:09Changes in the Appendicular Skeleton with Age
2.0K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
2.0K