在实体器官移植接收者中,细胞巨乳病毒感染管理的最新进展
Paolo Antonio Grossi1, Maddalena Peghin
1Infectious and Tropical Diseases Unit, Department of Medicine and Surgery, University of Insubria-ASST-Sette Laghi, Varese, Italy.
Current opinion in organ transplantation
|January 30, 2024
概括
人类细胞巨核病毒 (CMV) 是固体器官移植 (SOT) 后的一个主要问题. 新的CMV预防和治疗策略,包括T细胞免疫测定和新型抗病毒药物,正在改善患者的治疗结果.
科学领域:
- 传染性疾病 传染性疾病
- 移植免疫学 移植免疫学
- 病毒学 病毒学
背景情况:
- 人类细胞巨乳病毒 (CMV) 是固体器官移植 (SOT) 受体的重大传染性并发症.
- 目前的预防策略,如瓦尔根西克洛维尔预防,面临的挑战包括白血病和晚发性疾病.
研究的目的:
- 审查最近在SOT接收者中预防和治疗CMV疾病的进展.
- 突出优化移植后CMV管理的新兴策略.
主要方法:
- 在SOT中审查有关CMV预防和治疗的当前文献.
- 分析最近的临床发现和新出现的治疗选择.
主要成果:
- 瓦尔甘西克洛维尔预防是常见的,但有局限性.
- 特定于CMV的T细胞免疫检测可以个性化预防治疗的持续时间.
- 莱特莫维尔已被批准用于移植患者的预防.
- 结合CMV-RNAemia和CMV-DNAemia,有助于对病毒载量进行监测.
- 玛丽巴维尔为耐火/耐性CMV感染提供了一种新的治疗方法.
结论:
- 最近的进展为SOT中CMV预防和治疗提供了改进的方法.
- 个性化预防和新疗法解决了CMV管理当前的挑战.
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