注意缺陷/多动症障碍和自闭症谱系障碍与创伤后应激障碍的因果关系
Yuqing Song1,2, Yi Zhao3, Ancha Baranova4,5
1Peking University Sixth Hospital/Institute of Mental Health, Beijing.
Psychiatric genetics
|January 30, 2024
概括
注意缺陷/多动障碍 (ADHD) 和自闭症谱系障碍 (ASD) 与患上创伤后应激障碍 (PTSD) 的风险更高有关. 遗传因素表明,多动症和自闭症可能会使个体倾向于PTSD,但不是相反.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
背景情况:
- 注意缺陷/多动症 (ADHD) 和自闭症谱系障碍 (ASD) 是神经发育的疾病.
- 患有多动症和自闭症的个体有经历创伤的风险增加.
- ADHD,ASD和创伤后应激障碍 (PTSD) 之间的遗传联系尚未得到充分理解.
研究的目的:
- 为了调查ADHD,ASD和PTSD之间的遗传关联.
- 探索这些条件之间的潜在的双向因果关系.
主要方法:
- 对ADHD,ASD和PTSD的大型病例对照队伍进行了遗传相关性分析.
- 用两个样本的门德尔随机化分析来评估因果关系.
主要成果:
- 在PTSD和ADHD之间 (rg = 0.70) 和PTSD和ASD之间 (rg = 0.34) 发现了显著的积极遗传相关性.
- 对ADHD (OR = 1.14) 和ASD (OR = 1.04) 的遗传责任与创伤后应激障碍的风险增加有关.
- 没有证据表明,对PTSD的遗传责任会增加患ADHD或ASD的风险.
结论:
- ADHD和ASD可能会增加患PTSD的风险.
- 这种遗传倾向似乎是单向的,从ADHD/ASD到PTSD.
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