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血勒丁/阿迪波涅克丁比率与青春期前儿童的胰岛素抵抗指数之间的关联

Carolina Bravo^1,2, Verónica Mericq³, Ana Pereira²

¹Departamento de Nutrición, Diabetes y Metabolismo, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Archives of endocrinology and metabolism

|January 30, 2024

概括

莱普/阿迪波涅丁比率 (LAR) 与儿童的胰岛素耐药性有关. 这一比率,特别是与腰围 (TyG-WC) 相结合时,显示出与青春期前儿童的胰岛素抵抗标志物有着强烈的关联.

科学领域:

儿科内分泌学儿科内分泌学
代谢健康代谢健康
肥胖问题研究研究

背景情况:

胰岛素耐药性是青春期前儿童日益关注的问题,通常与肥胖有关.
莱普和阿迪波涅丁是代谢调节中的关键激素,它们的比率 (LAR) 可能反映了胰岛素敏感性.

研究的目的:

调查前青春期儿童队列中丁/皮内克丁比率 (LAR) 和各种胰岛素耐药替代品之间的关联.
为了确定哪种胰岛素抵抗替代品与LAR的联系最强.

主要方法:

在智利成长和肥胖队列研究 (GOCS) 中利用了来自968名智利青春期前儿童的数据.
测量了血胰岛素,瘦素和脂肪素;计算了胰岛素抵抗替代品,包括HOMA-IR,TG/HDL,TyG指数,TyG-BMI和TyG-WC.
采用多重线性和逻辑回归分析来评估关联.

主要成果:

血瘦素和LAR与BMIz-score有显著的相关性.
在对年龄和性别进行调整后,LAR与所有测试的胰岛素抵抗替代品显示出显著的关联.
三甘油-葡萄糖-腰围指数 (TyG-WC) 显示出与LAR (OR 2.44) 最强的关联.
即使对BMI z-score进行调整,LAR和TyG-WC之间的关联仍然显著 (OR 1.64).

结论:

莱普/阿迪波涅丁比率 (LAR) 与青春期前儿童常见的胰岛素耐药替代物密切相关.
三甘油-葡萄糖-腰围 (TyG-WC) 指数成为与LAR相关的最强大的替代标志物.
观察到的关联主要是由血瘦素水平驱动的,这与增加的脂肪度相关.

关键词:

胰岛素耐药性胰岛素耐药性是一种没有任何的Adiponectin.勒普丁是一种素.莱普/阿迪波内克的比例

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