在墨西哥试管婴儿计划中,hCG日和卵细胞成熟时的孕激素水平
Alfredo Cortés-Vazquez1, Denisse Veliz-Figueroa1, Karla Vargas-Estrada1
1Reproductive Endocrinology Department, Centro Médico Nacional 20 de Noviembre, Mexico City, Mexico.
JBRA assisted reproduction
|January 30, 2024
概括
人体胆固醇激素 (hCG) 一天的孕水平与在体外受精 (IVF) /细胞内精子注射 (ICSI) 周期中获取的成熟卵细胞相关. 更高的水平有利于高响应者,但不一定是低响应者.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精 (IVF)
- 细胞内质精子注射 (ICSI) 的方法
背景情况:
- 卵巢刺激方案旨在最大限度地提高IVF/ICSI的卵细胞产量.
- 孕激素水平在人类胆性腺激素 (hCG) 给药当天的作用是正在进行的研究的主题.
- 了解影响卵细胞成熟的因素对于成功的生育治疗至关重要.
研究的目的:
- 调查hCG一天血清孕激素水平与卵细胞成熟率之间的关联.
- 为了确定孕激素水平是否会影响IVF/ICSI的卵巢刺激期间检索到的成熟卵细胞数量.
主要方法:
- 对600名接受试管婴儿/ICSI的患者进行了回顾性观察性研究.
- 患者根据hCG一天的孕激素水平 (<1.5ng/ml和>1.5ng/ml) 分为两组.
- 统计分析包括斯皮尔曼·罗,线性回归,主要组件分析和学生的T测试.
主要成果:
- 在hCG日的孕激素水平和检索到的成熟卵细胞数量之间观察到正相关性.
- 卵巢反应较差的患者表现出最低的成熟率和成熟卵细胞数量.
- 孕激素水平>1.5 ng/ml与更高的成熟卵细胞数量有关,但没有改善成熟率.
结论:
- 在hCG日的血清孕激素水平升高与高响应者的成熟卵细胞增加有关.
- 在低反应者中,更高的孕激素水平似乎与最佳卵巢反应无关.
- 孕激素监测可以为预测特定患者群体的卵巢反应提供见解.
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