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终身LUTS:了解膀在过渡阶段的作用和影响,全面审查
George Bou Kheir1, Irina Verbakel1, Michel Wyndaele2
1Department of Urology, ERN Accredited Centrum, Ghent University Hospital, Ghent, Belgium.
Neurourology and urodynamics
|January 30, 2024
概括
下尿路症状 (LUTS) 是由盆腔相互作用影响的终身疾病. 了解这些机制,包括分子因素和脆弱性,是个性化的LUTS管理的关键.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 盆腔健康 盆腔健康
- 老年学是一门学科.
背景情况:
- 下尿路症状 (LUTS) 包含各种尿路和盆腔功能障碍.
- 这些症状可以从童年到老年表现出来,代表了持续的护理.
- 现有的研究为了解LUTS的终身性质提供了基础.
研究的目的:
- 为了提供一个全面的观点,对终身连续的下游尿路症状.
- 阐明LUTS在整个生命周期的潜在机制和临床影响.
- 探索 LUTS,骨盆器官交叉谈话和脆弱性之间的关系.
主要方法:
- 由五名国际专家组成的小组进行了叙事审查.
- 现有的关于终身LUTS的文献得到了批判性评估.
- 专家的见解通过网络研讨会讨论进行了综合.
主要成果:
- 儿童LUTS可能会持续或发展为膀活动不足或疼痛综合征等情况.
- 骨盆器官交叉交谈,涉及神经和非神经相互作用,解释了LUTS的终身性质.
- 血管压素受体和脆弱性被确定为影响LUTS的关键因素,对脆弱个体的治疗证据有限.
结论:
- 了解终身LUTS需要了解遗传,解剖,神经和分子机制.
- 需要进一步的研究来确定LUTS的预测生物标志物.
- 阐明骨盆交叉对话和分子签名可以实现个性化的LUTS管理.
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