针对性肺部输送的纳米药物:受体介导策略和替代方案
Wenhao Wang1, Ziqiao Zhong2, Zhengwei Huang2
1School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, Guangdong, PR China. panxin2@mail.sysu.edu.cn.
Nanoscale
|January 30, 2024
概括
肺部药物输送向纳米药物 (PDTNs) 通过改善药物积累和减少副作用来增强肺部疾病的治疗. 本综述分析了各种肺部疾病的PDTN策略,强调了挑战和机遇.
科学领域:
- 纳米医学是一种纳米医学.
- 肺部药物输送 肺部药物输送
- 有针对性的治疗方法
背景情况:
- 纳米药物的肺部药物输送对肺部疾病有希望,但缺乏特异性.
- 针对肺部输送的纳米药物 (PDTNs) 是为了增强肺损伤积累并最大限度地减少全身副作用而开发的.
- 了解肺部疾病的微观环境可以实现多种向策略,以提高药物递送效率.
研究的目的:
- 审查和分析目前肺部输送向纳米药物 (PDTNs) 的出版趋势.
- 总结报告的PDTN基于肺癌,感染,炎症和纤维化的受体介导策略.
- 讨论 PDTN 的替代设计策略,并确定发展瓶,挑战和机遇.
主要方法:
- 分析PDTN研究中的出版趋势.
- 用受体介导策略对特定肺部疾病 (肺癌,感染,炎症,肺纤维化) 报告的PDTN进行总结.
- 讨论替代设计策略,包括电荷调节,粘液透,刺激响应释放和磁性准.
主要成果:
- 在PDTNs的研究引起了显著的注意.
- 使用受体介导策略的PDTNs已在肺癌,感染,炎症和肺纤维化方面得到报道.
- 讨论了各种替代策略,如电荷调节,粘液增强,刺激响应传递和磁性准.
结论:
- PDTNs为向性肺病治疗提供了一种有前途的方法.
- 有多种策略可以设计PDTNs,以适应特定的肺病微环境.
- 解决目前的瓶对于推动PDTN开发和临床应用至关重要.
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