免疫抑制剂IGSF1作为癌症免疫治疗的潜在目标
Dong-In Koh1,2, Minki Lee1,2, Yoon Sun Park1,2,3
1Wellmarkerbio Co., Ltd., Seoul, Republic of Korea.
Cancer immunology research
|January 30, 2024
概括
研究人员确定免疫球蛋白超级家族成员1 (IGSF1) 是一种新的癌症标. 一种IGSF1特异性抗体,WM-A1,在增强抗瘤免疫力方面表现有前途,有可能克服当前免疫疗法的局限性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 针对PD-1/PD-L1和CTLA-4的第一代免疫检查点抑制剂 (ICI) 已经彻底改变了癌症治疗.
- 然而,很大一部分患者对现有的ICI没有反应,需要发现新的治疗点.
- 免疫球蛋白超级家族成员1 (IGSF1),一种膜糖蛋白,已与甲状腺功能有关,其在免疫反应中的作用在很大程度上尚未被探索.
研究的目的:
- 研究IGSF1作为癌症新型免疫治疗点的潜力.
- 开发和描述针对IGSF1的抗体,并评估其在促进抗瘤免疫力的有效性.
- 为了探索IGSF1抑制与现有的免疫检查点阻塞的组合疗法.
主要方法:
- 对瘤与正常组织以及具有不同PD-L1表达水平的非小细胞肺癌 (NSCLC) 细胞中的IGSF1表达的分析.
- 开发和描述针对IGSF1.1.的人类单克隆抗体 (WM-A1).
- 使用人性化的外周血液单核细胞 (PBMC) 的体外研究和使用同源性小鼠模型的体内研究来评估WM-A1的疗效.
- 与抗PD-1抗体联合治疗的评估.
主要成果:
- IGSF1主要表达在瘤中,与PD-L1高细胞相比,在PD-L1低的NSCLC细胞中表达增加.
- 开发的IGSF1特异性抗体WM-A1显示出强大的抗瘤免疫力.
- 在人性化的PBMC和小鼠模型中,WM-A1显示出显著的疗效,与抗PD-1疗法相结合时,具有附加效益.
结论:
- IGSF1代表了癌症免疫治疗的有前途的新型免疫标.
- IGSF1特异性抗体WM-A1提供了一个潜在的新疗法策略,可以克服当前ICI的局限性.
- 涉及IGSF1阻断的组合疗法可以提高癌症患者的治疗结果.
相关概念视频
Tumor Immunotherapy
526
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
526
Mitogens and the Cell Cycle
6.5K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K
Cancer-Critical Genes II: Tumor Suppressor Genes
7.4K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.4K
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Cancer Vaccines
367
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
367
Loss of Tumor Suppressor Gene Functions
4.8K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
4.8K


