在磁共振成像中的发现,用于重新定位局部晚期直肠癌
Suvi Marjasuo1,2, Laura Koskenvuo3, Anna Lepistö4,5
1Radiology, HUS Diagnostic Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland. suvi.marjasuo@helsinki.fi.
International journal of colorectal disease
|January 30, 2024
概括
在新辅助疗法后恢复MRI预测局部晚期直肠癌 (LARC) 的预后. 推迟手术的短期放射治疗 (SCRT-delay) 与长期化疗放射治疗 (LC-CRT) 的癌症结果相似.
科学领域:
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
- 诊断成像 诊断成像 诊断成像
背景情况:
- 新辅助疗法对于局部晚期直肠癌 (LARC) 是至关重要的.
- 通过重新设置磁共振成像 (MRI) 评估治疗反应对于预后至关重要.
- 对比不同的新辅助剂策略对于优化患者的治疗结果至关重要.
研究的目的:
- 评估LARC患者在新辅助疗法后重新进行MRI的预后意义.
- 为了比较长期化疗放射治疗 (LC-CRT) 与推迟手术 (SCRT-delay) 的短期放射治疗的瘤治疗结果.
主要方法:
- 在2016年1月至2019年4月期间治疗的267名LARC患者的回顾性分析.
- 患者接受LC-CRT或SCRT延迟作为新辅助治疗.
- 评估的结果包括总生存率 (OS) 和基于磁共振瘤回归度 (mrTRG) 的癌症特异性生存率 (CSS).
主要成果:
- 与SCRT延迟相比,LC-CRT显示出更高的1年,3年和5年的OS率 (P=0.017).
- 两组之间没有观察到CSS,组织学反应或局部复发率的显著差异.
- 良好的放射性反应 (mrTRG 1-3) 与明显更好的OS和CSS有关 (OS的P=0.023,CSS的P=0.048).
结论:
- 显示不良反应的MRI检测结果与LARC的预后较差有关.
- 在管理LARC方面,SCRT延迟似乎在瘤学上与LC-CRT相似.
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