在有或没有多发性硬化症的老年人中,额头状管完整性和抑郁症
Sarah E Cote1, Mark Wagshul2, Frederick W Foley3,4
1Department of Psychology, Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, USA. Scote1@mail.yu.edu.
概括
患有多发性硬化症 (MS) 的老年人经历更多的抑郁症. 左背侧前额皮质到骨核 (DLPFC-pn) 管道的下白质完整性与该组抑郁症症状的增加有关.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 精神病学是一个精神病学.
背景情况:
- 晚年抑郁症与老年人白质完整性降低有关.
- 多发性硬化症 (MS) 可能会影响前额下皮质电路,可能会影响情绪和认知.
研究的目的:
- 调查MS老年人的抑郁症得分和前额状白质完整性之间的关联.
- 为了比较患有MS的个体与健康对照人群之间的这些关联.
主要方法:
- 大脑MRI被用来评估白质完整性通过分数异构 (FA) 在特定的前额-状道 (DLPFC-pn和DLPFC-cn).
- 参与者包括患有多发性硬化症的老年人 (n=67) 和健康对照人 (n=74).
- 抑郁症使用老年抑郁症尺度进行测量.
主要成果:
- 患有MS的老年人报告的抑郁症症状比对照组更高.
- 左侧DLPFC-pn通道的下部FA与更高的抑郁症得分显著相关,特别是在多发性硬化症组.
- 对于其他通道或对照组中没有发现显著的关联.
结论:
- 这项研究提供了第一个证据,将左DLPFC-pn通道中白质完整性降低与患有MS的老年人抑郁症的恶化联系起来.
- 研究结果表明,这种特定通道的白质变化可能会导致这种人群的抑郁症.
相关概念视频
Depression: Overview
244
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
244
Cognitive Development During Adulthood
111
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
111


