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肠道细菌网络与多民族人口中的心血管疾病有关:HELIUS研究
Moritz V Warmbrunn1,2, Ulrika Boulund1,2,3, Judith Aron-Wisnewsky4,5
1Department of Internal and Vascular Medicine, Amsterdam University Medical Centers, Location AMC, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
肠道微生物影响心血管疾病 (CVD) 风险,特定的微生物网络显示种族差异. 一个关键的微生物群 (Christensenellaceae-Methanobrevibacter-Ruminococcaceae) 与降低心血管疾病风险和甘油三有关.
科学领域:
- 微生物组研究的研究.
- 心血管疾病 (CVD) 流行病学
- 人类遗传学 人类遗传学
背景情况:
- 肠道微生物群的组成因种族而异,并且与心血管疾病 (CVD) 有关.
- 了解特定种族的肠道微生物营养网络对于心血管疾病风险评估至关重要.
研究的目的:
- 调查肠道微生物营养网络与不同种族的CVD表型之间的关系.
- 确定特定的微生物种群及其在心血管疾病发展中的潜在因果作用.
主要方法:
- 分析了来自6个种族的3860个人的横截面数据 (HELIUS研究).
- 机器学习用于评估心血管疾病风险 (弗雷明汉分数) 和肠道微生物群组成,按种族分层.
- 两个样本的孟德尔随机化用于推断肠道微生物和心血管疾病事件之间的潜在因果关系.
主要成果:
- 微生物与心血管疾病风险的关联显示出种族特异性,有一些跨种族一致性.
- 阿克尔曼西亚尼菲拉 (Akkermansia muciniphila) 和鲁米诺可可科科 (Ruminococcaceae) UCG-002在特定种族群体中表现出对缺血性心脏病的保护作用.
- 在血脂,心血管疾病风险和Christensenellaceae-Methanobrevibacter-Ruminococcaceae (CMR) 微生物群之间发现了显著的反向关联.
结论:
- 特定的肠道微生物可能与心血管疾病事件有因果关系,可能具有特定种族的影响.
- 在南亚苏里南人中经常减少的CMR微生物网络与心血管疾病风险降低和较低的甘油三水平有关.
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