阅读和命名的分离在腹腔皮和皮皮层
Oscar Woolnough1,2, Nitin Tandon1,2,3
1Vivian L. Smith Department of Neurosurgery, McGovern Medical School at UT Health Houston, Houston, TX 77030, USA.
Brain : a journal of neurology
|January 30, 2024
概括
大脑刺激揭示了读取和命名的腹腔皮质 (vOTC) 中不同的区域. 这项研究阐明了vOTC的功能组织,这对于理解语言处理和预防手术后缺陷至关重要.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 神经语言学是一种神经语言学.
背景情况:
- 腹腔皮质 (vOTC) 损伤可能导致阅读 (无力学) 或命名 (缺血) 的选择性缺陷.
- 功能成像显示在vOTC中阅读和命名的重叠激活,与病变研究产生不和.
- 在vOTC中,阅读和命名的精确功能架构和分离性仍在争论中.
研究的目的:
- 解决关于vOTC组织阅读和命名的损伤和成像数据之间的矛盾.
- 以因果关系来确定读取和命名功能是否可以在vOTC内在个别层面上分离.
- 在vOTC中生成功能站点的人口级地图,用于阅读和命名.
主要方法:
- 在阅读段落和视觉命名任务期间,49名成年患者对vOTC的集中刺激.
- 在2829个站点使用电刺激 (50 Hz) 绘制语言映射.
- 对刺激效应的分析,以确定选择性地扰乱阅读,命名或两者的位置.
主要成果:
- 在vOTC中确定了不同的站点,这些站点选择性地破坏了阅读 (24站点) 或命名 (27站点).
- 发现了一个多式调节区域,刺激中断了阅读和命名 (75个站点).
- 已证实,中外vOTC与命名障碍更为相关,而后侧vOTC与特定阅读障碍更为相关.
结论:
- vOTC包含一个用于阅读和命名的异模区域,一个单模命名皮质,以及一个特定于阅读的视觉文字形式区域.
- 这些不同的角色可能与更广泛的语言网络中的连接性有关,而不仅仅是选择性调.
- 读取和命名的手术前映射对于接受vOTC切除的患者至关重要,以防止意外的缺陷.
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