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Updated: Aug 1, 2026

Osmotic Avoidance in Caenorhabditis elegans: Synaptic Function of Two Genes, Orthologues of Human NRXN1 and NLGN1, as Candidates for Autism
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Osmotic Avoidance in Caenorhabditis elegans: Synaptic Function of Two Genes, Orthologues of Human NRXN1 and NLGN1, as Candidates for Autism

Published on: December 11, 2009

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自闭症风险基因Scn2a和Ank2在新皮层金字塔细胞树突中的物理和功能融合

Andrew D Nelson1, Amanda M Catalfio2, Julie P Gupta2

  • 1Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.

Neuron
|January 30, 2024
PubMed
概括

安基林-B对于在神经元中定NaV1.2通道至关重要,这是理解自闭症谱系障碍 (ASD) 等神经发育障碍的关键发现. 它的功能障碍反映了与ASD相关的Scn2a基因突变中的缺陷.

关键词:
安基林 (ankyrin) 是一种脚.自闭症谱系障碍 自闭症谱系障碍轴突的初始段是轴的初始段.收 收 收 收 收 收树状的树状物刺激性 刺激性 刺激性在本地化,本地化.中部前额叶皮层中部前额叶皮层通道中的.突触突触突触是一个突触突触.

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...