在子中进行运动执行和取消的体下活动
Zlata Polyakova1,2,3, Nobuhiko Hatanaka1,2, Satomi Chiken1,2
1Division of System Neurophysiology, National Institute for Physiological Sciences, Okazaki 444-8585, Japan.
概括
甲状腺下核 (STN) 控制运动的执行和取消. 接收运动皮层输入的背部STN神经元准备,执行和取消计划的运动,具有方向选择性活动.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 基底腺功能 基底腺功能
背景情况:
- 脑下细胞核 (STN) 对自愿运动控制和运动障碍至关重要.
- 在运动执行和运动取消期间,STN神经元表现出改变的活动.
- 了解STN执行和取消功能之间的关系至关重要.
研究的目的:
- 为了研究背部亚thalamic核 (STN) 在运动执行和取消的作用.
- 检查STN活动和运动皮质输入在目标定向任务期间之间的关系.
主要方法:
- 在日式子 (Macaca fuscata) 中记录STN神经元活动,在目标定向的达到任务中.
- 包括Go,Cancel和NoGo试验,以区分与运动相关的活动.
- 刺激了主要运动皮层和补充运动区域的前肢区域.
主要成果:
- 在背部体运动区域内具有运动皮层输入的STN神经元在Go试验 (运动执行) 中显示了活动变化.
- 这些神经元的一个子集在取消试验 (运动取消) 中也显示了活动变化,并在延迟期间 (运动准备) 持续活动.
- 与运动相关的活动是方向选择性的,特别是在取消试验中,并且发生的时间足以启动或取消运动.
结论:
- 背部STN接收运动皮质输入,参与准备和执行运动.
- 背部STN在取消计划运动方面发挥着重要作用.
- 与执行相比,在运动取消期间,STN活动的方向选择性得到增强.
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