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在外围上腺刺激期间,一般性焦虑障碍中引起心跳的神经反应异常
Charles Verdonk1,2,3, Adam R Teed1, Evan J White1
1Laureate Institute for Brain Research, Tulsa, OK, USA.
概括
通用焦虑障碍 (GAD) 涉及到身体内部信号的异常处理. 这项研究在GAD患者中发现心脏整体感受改变,独立于大脑成像信号.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 心脏病学 心脏病学
背景情况:
- 通用焦虑障碍 (GAD) 的特点是出现过度兴奋的症状,这些症状似乎与生理状态脱节.
- 这表明,在患有GAD的个体中,处理身体内部信号 (内接) 可能存在功能障碍.
- 这种整体感知功能障碍的神经支需要进一步研究.
研究的目的:
- 调查GAD中整体感受功能障碍的神经机制.
- 检查心血管信号的上腺激素调制如何影响心脏内心接收,通过心跳唤起潜力 (HEP) 测量.
- 在心血管挑战期间将电生理学 (EEG) 和血中依赖氧气水平 (BOLD) 的fMRI信号关联起来.
主要方法:
- 一项随机,双盲,安慰剂控制的研究,使用同时进行脑电图和功能磁共振成像 (EEG-fMRI).
- 静脉注射异二醇 (一种外围上腺激动剂) 的0.5和2.0微克 (μg) 被用于扰乱心血管信号.
- 心跳唤起的潜在 (HEP) 幅度变化和大胆的fMRI信号在GAD和健康对比 (HC) 组的参与者中被记录下来.
主要成果:
- 与HC组相比,GAD组在0.5μg的异二醇输注期间显示出HEP振幅的显著更大,相反的方向变化.
- 在盐水输注期间,GAD患者的绝对HEP幅度比HC患者更大 (心血管度没有增加).
- 在2.0μg的异二醇输注期间,没有观察到HEP振幅的显著群体差异.
- 在关键大脑区域 (岛屿,vmPFC,dACC,杏仁体,体感皮层) 的fMRI信号与HEP效应没有相关.
结论:
- 这些发现提供了GAD中功能障碍的心脏整体受体的证据.
- 在上腺刺激期间,心脏整体受体的电生理学标志物可能会在GAD中改变,而不依赖于BOLD fMRI反应.
- 这突出了电生理学层面的特定神经过程,这些过程有助于GAD的感觉缺陷.
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