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上腺素通过α2A-上腺素受体保护耳外毛细胞损伤和噪音引起的听力损失

Chaoyong Tian¹, Yang Yang¹, Renfeng Wang¹

¹Department of Otolaryngology Head and Neck Surgery, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi, 710032, China.

BMC neuroscience

|January 30, 2024

概括

交感性缩并没有防止噪音引起的听力损失 (NIHL). 然而,上腺素可以通过α2A-上腺体受体防止外发细胞的氧化应激,这表明NIHL的潜在治疗策略.

科学领域:

耳声波排放耳声波排放耳声波排放
听觉神经科学听觉神经科学
听觉的细胞机制

背景情况:

耳交感系统影响听觉功能和易受噪声引起的听力损失 (NIHL).
反应性氧物种 (ROS) 的形成与NIHL的病原发生有关.
在对NIHL的耳保护中,交感内的作用需要进一步研究.

研究的目的:

为了研究上性瘤切除术 (SCGx) 对Sprague-Dawley大鼠NIHL的影响.
探索尾中的交感纤维对噪声暴露的保护机制.

主要方法:

在成年斯普雷格-道利大鼠中单边和双边SCG切除.
使用听觉脑干响应 (ABR) 和扭曲产物耳声发射 (DPOAEs) 的听觉功能评估.
通过免疫光测试对外毛细胞 (OHC) 数量和α2A-上腺素受体 (AR) 表达的评估;使用HEI-OC1细胞进行体外研究以探索机制.

主要成果:

单边或双边的SCGx都没有提供对噪声引起的耳损伤的保护.
上腺素 (NE) 抑制了H2O2诱导的氧化损伤和HEI-OC1细胞中的细胞死亡.
在OHC中,NE证明了对可能由α2A-AR介导的氧化应激的保护作用.

结论:

交感内置对通过α2A-AR减少OHC中的氧化损伤对耳对声学创伤的敏感性有轻微影响.
上腺素为预防NIHL提供了潜在的治疗策略.
向α2A-AR通路可能为NIHL治疗提供一种新的方法.

关键词:

噪音引起的听力损失外部毛细胞是什么?上层子宫腺节的发生.同情神经系统的同情神经系统.α2A-上腺素受体

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