从A到E:联合维生素对抗中风风险-A系统性审查和网络元分析
Shashank Tripathi1, Manabesh Nath1, Shubham Misra2
1Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
European journal of clinical investigation
|January 30, 2024
概括
某些维生素,包括维生素D,C,B6,A,B复合和叶酸,在降低中风风险方面表现有前途. 需要进一步的研究来证实这些发现,并制定明确的补充预防中风的指导方针.
科学领域:
- 营养科学 营养科学
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 脑卒中是全球主要的健康问题,需要有效的预防策略.
- 研究维生素补充剂在降低中风风险中的作用至关重要.
研究的目的:
- 进行网络元分析,评估各种维生素治疗与安慰剂在中风预防方面的疗效.
- 根据维生素在预防中风方面的有效性来对维生素进行排名.
主要方法:
- 在多个数据库 (PubMed,EmBASE,Web of Science,clinicaltrials.gov,Google Scholar) 进行系统的电子搜索,截至2023年5月.
- 频率网络的元分析以计算聚合风险比率 (RR) 和95%置信区间 (CI).
- 通过P-score分析,根据预防中风的有效性对维生素进行排名.
主要成果:
- 分析包括56项研究 (17项RCT,39项队列研究).
- 维生素A,B复合物,B6,叶酸,C和D与降低中风风险显著相关.
- 维生素D (p-score=0.91) 和维生素C (p-score=0.79) 在中风预防有效性方面排名最高.
结论:
- 发现了维生素A,B复合物,B6,叶酸,C和D与降低中风风险之间的显著关联.
- 研究结果支持维生素干预预防中风的潜在益处.
- 需要进一步进行高质量的临床试验来验证这些结果并指导补充策略.
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