儿科急性淋巴细胞白血病患者的结局与肠道穿孔
Gustavo de Oliveira Canedo1, Aodhnait S Fahy2, Eveline Lapidus Krol2
1Division of Pediatric Hematology-Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Pediatric blood & cancer
|January 31, 2024
概括
肠道穿孔在接受急性淋巴细胞白血病 (ALL) 治疗的儿童中是一种罕见但严重的并发症. 早期的手术是有效的,允许患者继续ALL治疗,具有良好的长期结果.
科学领域:
- 儿科瘤学 儿科瘤学
- 外科胃肠道外科手术
- 血液学 血液学 血液学
背景情况:
- 肠道穿孔是儿科急性淋巴细胞白血病 (ALL) 治疗期间罕见但严重的并发症.
- 这种并发症可能对患者产生重大长期后果.
研究的目的:
- 研究ALL儿童肠道穿孔的流行病学和临床特征.
- 为了分析外科病理,寻找致病因素.
- 评估对治疗,营养和患者结果的影响.
主要方法:
- 从2000年1月到2020年10月,对患有ALL和肠道穿孔的儿童进行了回顾性图表审查.
- 数据包括人口统计,ALL特征,穿孔细节,病理学,治疗调整和结果.
主要成果:
- 在1840人中,有13人 (0.7%) 在所有患者中经历了肠道穿孔,主要是在诱导阶段 (91%).
- 大多数患者经历了腹腔切除术与口腔切除术;没有人死于手术或营养不良.
- 病理学揭示了炎症,一些病例显示白血病透或微生物. 所有患者都恢复了ALL治疗.
结论:
- 早期的手术干预是小儿ALL患者肠道穿孔的成功治疗方法.
- 穿孔主要发生在诱导阶段,没有特定的原因.
- 患者可以在康复期间接受化疗,并继续ALL治疗,对结果没有明显的影响.
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