血红蛋白C特征和血红蛋白C疾病的血栓形成风险:系统性审查
Jeremy W Jacobs1, Deva Sharma2,3, Laura D Stephens4
1Special Coagulation Laboratory, Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
British journal of haematology
|January 31, 2024
概括
患有血红蛋白C特征 (HbAC) 或疾病 (HbCC) 的人可能面临血栓形成的风险增加. 这份对782名个人的综述表明,HbC条件可能是血液凝块的诱导因素.
科学领域:
- 血液学 血液学 血液学
- 血管医学 血管医学
- 血栓形成研究研究
背景情况:
- 与血红蛋白C特征 (HbAC) 和血红蛋白C疾病 (HbCC) 相关的血栓形成风险尚不清楚.
- 与野生型血红蛋白 (HbAA) 患者相比,患有HbCC的个体表现出慢性血液溶解,血粘度升高和变化的风湿学.
- 这些生理变化理论上表明,可能会增加血栓形成的风险.
研究的目的:
- 系统地审查和调查HbAC和/或HbCC与血栓形成之间的关联.
- 评估当前有关血栓事件的证据,对具有血红蛋白C变体的个体.
主要方法:
- 进行了系统的文献审查.
- 包括的研究包括782名HbAC (n=694) 或HbCC (n=88) 个体.
- 在受影响个体中提取了静脉血栓栓塞 (VTE) 和动脉血栓症的数据.
主要成果:
- 22项研究符合纳入标准.
- 报道了15项关于静脉动脉瘤的研究,7项关于动脉血栓的研究.
- 两项研究表明,与HbAA相比,HbAC的VTE风险可能会增加,特别是在孕妇中 (RR 3.7).
结论:
- 这一系统性审查是迄今为止对HbC特征或疾病和血栓形成的患者进行的最广泛的评估.
- 尽管有局限性,但研究结果表明,血红蛋白C可能是导致血栓形成的风险因素.
- 需要进行进一步的前性队列研究,以确定这一群体的血栓形成风险.
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