揭示帕金森病精神病的评估差距:一个全面的审查
Graziella Mangone1,2,3, Michelle H S Tosin1, Christopher G Goetz1
1Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.
概括
目前的帕金森病精神病 (PDP) 措施侧重于症状严重程度,忽视功能影响. 需要进行新的评估,以捕捉PDP在患者日常生活中的全部范围.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
- 临床结果评估临床结果评估
背景情况:
- 帕金森病精神病 (PDP) 是一种复杂的疾病,需要精确的测量.
- 现有的PDP临床结果评估 (COA) 措施在综合评估方面存在挑战.
- 可靠的COA工具对于PDP的临床实践和研究都至关重要.
研究的目的:
- 确定目前对帕金森病精神病 (PDP) 的临床结果评估 (COA) 中的测量差距.
- 在现有的评估工具中评估PDP症状和功能影响的覆盖范围.
- 为制定更全面的PDP评估策略提供信息.
主要方法:
- 根据PRISMA-ScR指南进行了范围审查.
- 在国际数据库中使用了三步式的搜索策略,用于帕金森病 (PD),精神病和COA关键词.
- 分析了628项研究,将32个COA中的432个PDP项目按域和子域分类.
主要成果:
- 包括32个COA,其中19个是PD特定的,包含266个项目 (ClinRO,PRO,ObsRO).
- 在27个COA中,89.4%的项目集中在PDP症状严重程度上.
- 只有9.7%的项目评估了PDP对日常工作的影响.
结论:
- 目前的PDP测量优先考虑症状严重程度而不是功能影响.
- 现有的COA不足以解决PDP如何影响患者的日常生活.
- 开发具有新项目的新COA是必要的,以便在PDP评估中优先考虑功能影响.
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