肥胖性聚烯微塑料暴露破坏了肠-肝-脂肪轴
Jingjing Zhao1,2, Ngozi Adiele3, Daniel Gomes1,3
1Division of Environmental Medicine, Department of Medicine, School of Medicine, Christina Lee Brown Envirome Institute, University of Louisville, Louisville, Kentucky 40202, USA.
概括
聚烯微塑料 (MP) 通过影响肠-肝-脂肪轴,导致体重增加和改变新陈代谢. 饮食干预,如delphinidin,可以减轻这些不良健康影响.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 代谢性疾病 代谢性疾病
背景情况:
- 微塑料 (MP) 是普遍存在的环境污染物.
- 摄入MP的健康后果在很大程度上是未知的.
- 之前的研究将聚乙烯 (PS) 珠子的消费与小鼠的肠道失调和代谢功能障碍联系起来.
研究的目的:
- 研究PS对肠-肝-脂肪轴的系统代谢影响.
- 评估PS对肝功能和中间代谢的影响.
- 评估饮食干预措施对抗PS诱导的代谢变化的潜力.
主要方法:
- 在13周的时间里,C57BL/6J小鼠在饮用水中 (1微克/毫升) 暴露于0.5和5微米的PS珠.
- 评估了新陈代谢指数,肝功能和肠-肝-脂肪轴标志物.
- 用delphinidin治疗的小鼠被评估其对PS诱导的代谢变化的影响.
主要成果:
- 暴露于PS增强了体重增加和脂肪组织扩张,脂肪F4/80+巨细胞增加.
- 观察到肝脏:体重比率下降和肝脏Farnesoid X受体和肝脏X受体信号的改变.
- PS增加了肝脏胆固醇,改变了胆酸,并调节了cAMP和PPAR信号通路.
结论:
- 聚烯微塑料表现出肥胖性质,扰乱肠-肝-脂肪轴,改变核受体信号和代谢.
- 饮食干预措施,如delphinidin,在减轻PS消费的不良代谢影响方面显示出希望.
- 需要进一步的研究,以了解微塑料对健康的影响的全部范围,并制定有效的对策.
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